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CaI2-Catalyzed Direct Transformation of N-Alloc-, N-Troc-, and N-Cbz-Protected Amines to Asymmetrical Ureas

Abstract

A novel and facile CaI2-catalyzed direct synthesis of asymmetrical ureas from N-Alloc-, N-Troc-, and N-Cbz-protected amines is developed. In this study, efficient reaction of Alloc-, Troc-, and Cbz-carbamate with amines in the presence of catalytic CaI2 successfully generated various asymmetrical ureas. This catalytic synthetic procedure provided the desired ureas via reactions of these protected aromatic and aliphatic amines with various amines in high yields without side products. This suggests that novel direct synthesis of ureas from Alloc-, Troc-, and Cbz-carbamates can provide a promising approach for the synthesis of useful ureas.

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Publication details

The article was received on 15 Jun 2019, accepted on 06 Aug 2019 and first published on 07 Aug 2019


Article type: Paper
DOI: 10.1039/C9NJ03111A
New J. Chem., 2019, Accepted Manuscript

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    CaI2-Catalyzed Direct Transformation of N-Alloc-, N-Troc-, and N-Cbz-Protected Amines to Asymmetrical Ureas

    V. H. Tran and H. Kim, New J. Chem., 2019, Accepted Manuscript , DOI: 10.1039/C9NJ03111A

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