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Transition-Metal-Free catalyzed [3+2] Cycloadditions/Oxidative Aromatization Reactions for the synthesis of Annulated Indolizines

Abstract

A transition-metal-free catalyzed [3+2] cycloadditions/oxidative aromatization three-component reactions for direct construction of pyrrolo[3,4-a]indolizine-1,3(2H)-diones via pyridinium ylides has been successfully reported. This method utilizes readily available between pyridines, acetophenones and maleimides as starting materials in the presence of TBAI (N-tetrabutylammonium iodide)/TBHP (tert-butyl hydroperoxide), wide substrate scope and moderate to good yields, avoiding the use of metal catalysts and generation of halide.

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Publication details

The article was received on 13 Jun 2019, accepted on 04 Oct 2019 and first published on 07 Oct 2019


Article type: Paper
DOI: 10.1039/C9NJ03076J
New J. Chem., 2019, Accepted Manuscript

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    Transition-Metal-Free catalyzed [3+2] Cycloadditions/Oxidative Aromatization Reactions for the synthesis of Annulated Indolizines

    Q. Zhang, B. Wang, H. Ma and K. Ablajan, New J. Chem., 2019, Accepted Manuscript , DOI: 10.1039/C9NJ03076J

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