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An instantaneous fluorescent probe for detecting hydrogen sulfide in biological systems

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Abstract

Hydrogen sulfide (H2S), known as a gaseous signaling molecule, can regulate the intracellular redox status and some crucial signaling processes in the human system. Due to the intricacy of physiological reactivity and rapid catabolism of H2S in biosystems, rapid and efficient methods to monitor H2S in vivo and in vitro are highly desired. With this goal, we herein report an ultrafast fluorescent probe, CA, which was developed for the real-time detection of H2S with high sensitivity and good selectivity. CA displayed a 217-fold fluorescence enhancement in response to H2S with a detection limit of 3.5 nM. With the assistance of a confocal fluorescence microscope, we demonstrated that the probe could be applied for monitoring H2S in living cells and in zebrafish.

Graphical abstract: An instantaneous fluorescent probe for detecting hydrogen sulfide in biological systems

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Publication details

The article was received on 31 May 2019, accepted on 22 Jul 2019 and first published on 01 Aug 2019


Article type: Paper
DOI: 10.1039/C9NJ02849H
New J. Chem., 2019, Advance Article

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    An instantaneous fluorescent probe for detecting hydrogen sulfide in biological systems

    Q. Fang, H. Xiong, L. Yang, B. Wang and X. Song, New J. Chem., 2019, Advance Article , DOI: 10.1039/C9NJ02849H

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