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A naphthalimide-indole fused chromophore-based fluorescent probe for the detection of biothiol with red emission and a large Stokes shift

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Abstract

In this work, a fluorescent probe, 1, using naphthalimide-indole as a fluorophore and a 2,4-dinitrobenzene sulfonyl group as a recognition site for biothiols (GSH, Cys and Hcy) was developed. The probe can work in aqueous media with a rapid response time (within 4 min). In the detection of biothiols, the probe showed red emission (590 nm), low detection limits (8.97 × 10−9 M for GSH, 9.87 × 10−9 M for Cys, and 1.02 × 10−8 M for Hcy) and a 143 nm Stokes shift. Moreover, this probe exhibited potential practical applications for detecting biothiols in living cells.

Graphical abstract: A naphthalimide-indole fused chromophore-based fluorescent probe for the detection of biothiol with red emission and a large Stokes shift

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Publication details

The article was received on 25 May 2019, accepted on 29 Jul 2019 and first published on 29 Jul 2019


Article type: Paper
DOI: 10.1039/C9NJ02709B
New J. Chem., 2019, Advance Article

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    A naphthalimide-indole fused chromophore-based fluorescent probe for the detection of biothiol with red emission and a large Stokes shift

    Y. Rong, C. Wang, P. Chuai, Y. Song, S. Zhou, P. Hou, X. Liu, L. Wei and X. Song, New J. Chem., 2019, Advance Article , DOI: 10.1039/C9NJ02709B

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