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Water-soluble diboronic acid-based fluorescent sensors recognizing D-sorbitol

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Abstract

Herein, several boronic acid-based sensors were reported selectively recognizing D-sorbitol in aqueous solution. The fluorescence of sensor 15c was enhanced by 1.5-fold when combined with a low concentration of D-sorbitol (8.88 μM), and the fluorescence enhanced by 0.6-fold after binding to D-fructose, while it did not change obviously when combined with other carbohydrates, including D-arabinose, D-galactose, D-mannose, D-ribose, D-maltose, D-xylose, D-glucose and D-glucosamine. Fluorescence tests were carried out in DMSO/PBS (pH 9, 0.1 M) solution (1 : 99, v/v), at room temperature, which indicated that the sensors are water-soluble. In addition, competition studies showed that sensor 15c works well as a D-sorbitol-specific fluorescence sensor in both the absence and presence of carbohydrate interferents. And sensor 15c has a high binding constant (10 922 ± 776 M−1) and a low limit of detection (6.91 × 10−7 M) at pH 9 among the investigated sensors toward D-sorbitol. Furthermore, sensor 15c was applied to the analysis of real samples (D-sorbitol for oral administration). These studies indicated that sensor 15c may serve as a potential tool to detect the content of D-sorbitol in drugs and food products.

Graphical abstract: Water-soluble diboronic acid-based fluorescent sensors recognizing d-sorbitol

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Publication details

The article was received on 21 May 2019, accepted on 01 Aug 2019 and first published on 03 Aug 2019


Article type: Paper
DOI: 10.1039/C9NJ02636C
New J. Chem., 2019, Advance Article

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    Water-soluble diboronic acid-based fluorescent sensors recognizing D-sorbitol

    G. Fang, Z. Bian, D. Liu, G. Wu, H. Wang, Z. Wu and Q. Yao, New J. Chem., 2019, Advance Article , DOI: 10.1039/C9NJ02636C

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