Glutathione responsive poly(HPMA) conjugate nanoparticles for efficient 6-MP delivery

Weibing Xu; Guichen Li; Haitao Long; Guorui Fu; Lumei Pu

doi:10.1039/C9NJ02582K

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Glutathione responsive poly(HPMA) conjugate nanoparticles for efficient 6-MP delivery†

Weibing Xu,

*^a Guichen Li,^b Haitao Long,^a Guorui Fu^a and Lumei Pu*^a

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* Corresponding authors

^a College of Science, Gansu Agriculture University, Lanzhou 730000, Gansu Province, P. R. China
E-mail: xuwb@gsau.edu.cn, pulm@gsau.edu.cn

^b Gansu Provincial Key Laboratory of Aridland Crop Science, Gansu Agricultural University, Lanzhou 730070, China

Abstract

The anticancer drug 6-MP was covalently bonded to the –OH group of poly(HPMA) via a glutathione-responsive carbonyl vinyl sulfide linker. In vitro simulation assay demonstrated that the poly(HPMA)–PTA conjugate exhibited a markedly enhanced antitumor effect on HepG2 cells.

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Article information

DOI: https://doi.org/10.1039/C9NJ02582K
Article type: Letter
Submitted: 19 May 2019
Accepted: 05 Jul 2019
First published: 10 Jul 2019

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New J. Chem., 2019,43, 12215-12220

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Glutathione responsive poly(HPMA) conjugate nanoparticles for efficient 6-MP delivery

W. Xu, G. Li, H. Long, G. Fu and L. Pu, New J. Chem., 2019, 43, 12215 DOI: 10.1039/C9NJ02582K

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New Journal of Chemistry

Glutathione responsive poly(HPMA) conjugate nanoparticles for efficient 6-MP delivery†

Abstract

Supplementary files

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Glutathione responsive poly(HPMA) conjugate nanoparticles for efficient 6-MP delivery

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