Issue 36, 2019

Immobilization of an acid–base cooperative catalyst on MCM-41 as a heterogeneous approach for the asymmetric cyanoethoxycarbonylation of isatins

Abstract

A novel, highly efficient and recyclable quinine thiourea-based catalyst grafted on MCM-41 mesoporous silica was synthesized and explored as a heterogeneous catalyst for the cyanoethoxycarbonylation of isatin. MCM-41 has a high specific surface area and pore volume that allow maximum catalyst incorporation into pores. The catalyst was characterized by various sophisticated analytical techniques, including X-ray powder diffraction (XRD), TEM, thermogravimetric analysis (TGA), FTIR, BET surface area analysis, and 13C CP-MAS NMR spectroscopy. The catalyst proved efficient for various isatin derivatives to provide good yields with enantioselectivity of up to 98%. Further, the catalyst works well for up to five cycles without losing its activity.

Graphical abstract: Immobilization of an acid–base cooperative catalyst on MCM-41 as a heterogeneous approach for the asymmetric cyanoethoxycarbonylation of isatins

Supplementary files

Article information

Article type
Paper
Submitted
15 May 2019
Accepted
12 Aug 2019
First published
14 Aug 2019

New J. Chem., 2019,43, 14511-14517

Immobilization of an acid–base cooperative catalyst on MCM-41 as a heterogeneous approach for the asymmetric cyanoethoxycarbonylation of isatins

A. Ansari, P. Patel, G. Kumar and N. H. Khan, New J. Chem., 2019, 43, 14511 DOI: 10.1039/C9NJ02515D

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