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Copper-mediated synthesis of quinazolin-4(3H)-ones from N-(quinolin-8-yl)benzamide and amidine hydrochlorides

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Abstract

An efficient copper-mediated tandem C(sp2)–H amination to provide quinazolinones from N-(quinolin-8-yl)benzamide and amidine hydrochlorides has been developed. It can afford rather complex products in a single step synthesis from easily available starting materials using 8-aminoquinoline as a removable bidentate directing group. The features of this reaction are it being simple to operate and avoiding sensitive and expensive metals, and it provides an approach for the construction of polycyclic molecules in the area of organic chemistry.

Graphical abstract: Copper-mediated synthesis of quinazolin-4(3H)-ones from N-(quinolin-8-yl)benzamide and amidine hydrochlorides

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Publication details

The article was received on 06 May 2019, accepted on 21 Jul 2019 and first published on 22 Jul 2019


Article type: Paper
DOI: 10.1039/C9NJ02311A
New J. Chem., 2019, Advance Article

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    Copper-mediated synthesis of quinazolin-4(3H)-ones from N-(quinolin-8-yl)benzamide and amidine hydrochlorides

    Z. Ban, X. Cui, F. Hu, G. Lu, N. Luo and G. Huang, New J. Chem., 2019, Advance Article , DOI: 10.1039/C9NJ02311A

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