Facile detection of organophosphorus nerve agent mimic (DCP) through a new quinoline-based ratiometric switch
In this paper, a quinoline-based (BIMQ) probe has been developed which displays a ratiometric detection of organophosphorus (OP) chemical vapor threat, DCP. Upon addition of the nerve agent mimic diethyl chlorophosphate (DCP), a fluoroscence color change from blue to cyan was observed. The chemodosimeter (BIMQ) undergoes nucleophilic substitution reaction with DCP followed by a ring closure to yield the final product and shows a explicit fluorescence response towards DCP. The probe (BIMQ) selctively detects DCP over other toxic analytes. Now the detection limit of BIMQ for DCP was established to be in the order of 10-8 M in solution phase which suggests that BIMQ is efficient in detecting DCP in very minute level. This ratiometric switch has a potential application as a portable kit for detecting DCP vapour with high sensitivity. TDDFT calculations have been carried out in order to unveil the electronic properties theoretically.