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Issue 40, 2019
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Synthesis and comparison of linear and hyperbranched multivalent glycosides for C-type lectin binding

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Abstract

Linear and hyperbranched polyglycerol-based mannosides and fucosyllactosides were developed as nanomolar binders of mannose binding lectin (MBL) and DC-SIGN using label free microscale thermophoresis (MST) and surface plasmon resonance (SPR) techniques, respectively. While there was a small preference for hyperbranched polyglycerols in the case of MBL inhibitors, a clear advantage of ligand presentation on linear polyglycerol scaffolds was observed for DC-SIGN.

Graphical abstract: Synthesis and comparison of linear and hyperbranched multivalent glycosides for C-type lectin binding

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Publication details

The article was received on 18 Apr 2019, accepted on 02 Sep 2019 and first published on 11 Sep 2019


Article type: Paper
DOI: 10.1039/C9NJ02018G
New J. Chem., 2019,43, 16012-16016

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    Synthesis and comparison of linear and hyperbranched multivalent glycosides for C-type lectin binding

    P. Kiran, S. Kumari, J. Dernedde, R. Haag and S. Bhatia, New J. Chem., 2019, 43, 16012
    DOI: 10.1039/C9NJ02018G

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