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Controllable C2 arylation and C3 diazenylation of indoles with arytriazenes under ambient conditions

Abstract

An efficient and regio-divergent method for both C2 arylation and C3 diazenylation of C2,C3-unsubstituted indoles with arytriazenes was developed. At room temperature, both reactions were carried out with HPF6/ionic liquids (ILs) as the promoter. The C2 arylation and C3 diazenylation activated by HPF6/ILs show a remarkable reactivity, which results in corresponding products with yields up to 99%. Notably, the practicability of the protocol was further demonstrated via gram-scale operations, late-stage modification and the reusability of ILs.

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Supplementary files

Publication details

The article was received on 04 Apr 2019, accepted on 15 May 2019 and first published on 15 May 2019


Article type: Paper
DOI: 10.1039/C9NJ01728C
New J. Chem., 2019, Accepted Manuscript

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    Controllable C2 arylation and C3 diazenylation of indoles with arytriazenes under ambient conditions

    Y. Liu, X. Ma, G. Wu, Z. Liu, X. Yang, B. Wang, C. Liu, Y. Zhang and Y. Huang, New J. Chem., 2019, Accepted Manuscript , DOI: 10.1039/C9NJ01728C

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