Controllable C2 arylation and C3 diazenylation of indoles with arytriazenes under ambient conditions
An efficient and regio-divergent method for both C2 arylation and C3 diazenylation of C2,C3-unsubstituted indoles with arytriazenes was developed. At room temperature, both reactions were carried out with HPF6/ionic liquids (ILs) as the promoter. The C2 arylation and C3 diazenylation activated by HPF6/ILs show a remarkable reactivity, which results in corresponding products with yields up to 99%. Notably, the practicability of the protocol was further demonstrated via gram-scale operations, late-stage modification and the reusability of ILs.