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Biocompatible bovine serum albumin stabilized platinum nanoparticles for the oxidation of morin

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Abstract

The development of monodisperse platinum nanoparticles with high biocompatibility for organic dye treatment has been drawing great interest. Herein, bovine serum albumin (BSA) was used to stabilize different platinum nanoparticles (Ptn@BSA NPs, n = 10, 15, and 20), where the Pt metal precursor (K2PtCl4) was incubated with BSA solution, followed by the addition of excess NaBH4 as a reducing agent. The prepared Ptn@BSA NPs had small size with a narrow distribution. They also showed good catalytic activity towards morin. Transmission electron microscopy (TEM) images demonstrated that the average sizes of Pt10@BSA, Pt15@BSA and Pt20@BSA were 1.70 ± 0.39, 2.15 ± 0.42 and 3.11 ± 0.72 nm, respectively. Dynamic light scattering (DLS) results showed that the hydrodynamic sizes of Pt10@BSA, Pt15@BSA and Pt20@BSA were 4.25, 6.57 and 8.84 nm, and the corresponding zeta potentials were −31.23, −30.20 and −29.77 mV, respectively. In addition, the oxidation of morin using Ptn@BSA NPs followed a pseudo-first-order reaction in the presence of H2O2. The apparent rate constant Kapp was dependent on the concentration of Ptn@BSA NPs, morin and H2O2. Ptn@BSA NPs expedited the formation of hydroxyl radicals (˙OH) from H2O2. More importantly, Ptn@BSA NPs were highly biocompatible towards HeLa cells. Taken together, Ptn@BSA could be employed as an eco-friendly catalyst to treat organic dyes in the future.

Graphical abstract: Biocompatible bovine serum albumin stabilized platinum nanoparticles for the oxidation of morin

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Publication details

The article was received on 19 Feb 2019, accepted on 06 May 2019 and first published on 06 May 2019


Article type: Paper
DOI: 10.1039/C9NJ00887J
New J. Chem., 2019, Advance Article

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    Biocompatible bovine serum albumin stabilized platinum nanoparticles for the oxidation of morin

    S. Yu, Y. Cui, X. Guo, S. Chen, H. Sun, L. Wang, J. Wang, Y. Zhao and Z. Liu, New J. Chem., 2019, Advance Article , DOI: 10.1039/C9NJ00887J

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