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tert-Butyl(3-cyano-4,6-dimethylpyridin-2-yl)carbonate as a green and chemoselective N-tert-butoxycarbonylation reagent

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Abstract

The use of tert-butyl(3-cyano-4,6-dimethylpyridin-2-yl)carbonate as a chemoselective tert-butoxycarbonylation reagent for aromatic and aliphatic amines has been demonstrated. To gain insight into this reaction, in situ React IR technology was used to confirm the effectivity and chemoselectivity of this novel Boc reagent. The reaction was carried out chemoselectively in high yield under mild, environment-friendly conditions and was completed quickly within 1 hour. Simultaneously, the Boc carrier was easily recyclable, and has great application prospects for industrial production.

Graphical abstract: tert-Butyl(3-cyano-4,6-dimethylpyridin-2-yl)carbonate as a green and chemoselective N-tert-butoxycarbonylation reagent

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Publication details

The article was received on 19 Feb 2019, accepted on 27 Mar 2019 and first published on 27 Mar 2019


Article type: Paper
DOI: 10.1039/C9NJ00885C
Citation: New J. Chem., 2019, Advance Article

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    tert-Butyl(3-cyano-4,6-dimethylpyridin-2-yl)carbonate as a green and chemoselective N-tert-butoxycarbonylation reagent

    F. Du, Q. Zhou, Y. Fu, H. Zhao, Y. Chen and G. Chen, New J. Chem., 2019, Advance Article , DOI: 10.1039/C9NJ00885C

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