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Fabrication of glucose-responsive and biodegradable copolymer membrane for controlled release of insulin at physiological pH

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Abstract

A glucose-responsive and biodegradable copolymer, poly(ε-caprolactone)-b-poly(2-phenylboronic ester-1,3-dioxane-5-ethyl)methylacrylate (PCL-b-PPBDEMA), was synthesized by the combination of ring-opening polymerization (ROP) and atom transfer radical polymerization (ATRP). The diblock copolymer could be easily prepared as a membrane containing insulin via a solution casting approach. The crystalline behaviour and thermal properties were investigated by POM and DSC. The results indicated that the PPBDEMA segments could destroy the crystallizability of the PCL segments. Glucose molecules could react with PPBDEMA, which led to the breakage of the phenylboronic acid molecules from the PBDEMA groups. PCL-b-PPBDEMA copolymer membranes as intelligent carriers could realize controlled insulin release via adjusting the glucose concentration. At the physiological pH, the membrane revealed a higher release rate of insulin after immersion in glucose solutions with high concentrations than that in glucose solutions with lower concentrations. In vitro cytotoxicity assays showed that the membrane is almost noncytotoxic.

Graphical abstract: Fabrication of glucose-responsive and biodegradable copolymer membrane for controlled release of insulin at physiological pH

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Publication details

The article was received on 11 Feb 2019, accepted on 23 Apr 2019 and first published on 23 Apr 2019


Article type: Paper
DOI: 10.1039/C9NJ00729F
New J. Chem., 2019, Advance Article

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    Fabrication of glucose-responsive and biodegradable copolymer membrane for controlled release of insulin at physiological pH

    Y. Shen, Z. Xu, L. Li, W. Yuan, M. Luo and X. Xie, New J. Chem., 2019, Advance Article , DOI: 10.1039/C9NJ00729F

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