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Polydopamine-coated NaGdF4:Dy for T1/T2-weighted MRI/CT Multimodal Imaging-guided Photothermal Therapy

Abstract

The development of biocompatible theranostic agents with imaging and therapeutic function is urgently desired for biomedicine and nanoscience.Herein, a novel polydopamine (PDA) coated lanthanide-based nanocomposite NaGdF4:Dy@PDA-PEG-FA (NaGdF4:Dy@PPF) has been succesfully constructed for early diagnosis and treatment of tumor. MTT assay, histological analysis and the body weight changes of mice unambiguously revealed that this agent had relatively low cytotoxicity and negligible tissue damage. Due to the strong NIR absorption of PDA, this nanocomposite could be triggered effectively by 808 nm laser irradiation to produce an excellent photothermal conversion efficiency of 32.3%. Furthermore, NaGdF4:Dy@PPF displayed high longitudinal (r1 = 1.27 mM-1 s-1) and transverse (r2 = 126.0 Mm-1 s-1) relaxivities, and strong X-ray attenuation characteristic (43.56 HU L g-1). And T1/T2-weighted MRI and CT imaging in vivo confirmed that is nanocomposites could induce significant contrast-enhancement effect on tumor at 24 h post injection. In vivo experiments, the NaGdF4:Dy@PPF indicated a synergistic effect of PTT and targeting, resulting in efficient ablation of 4T1 cells and inhibition of tumor growth at 808 nm irradiation. All these results demonstrated that this multifunctional nanoplatform have potential application as a novel multimodal imaging-guided PTT agent for early diagnosis and therapy of tumors.

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Publication details

The article was received on 31 Jan 2019, accepted on 03 Apr 2019 and first published on 10 Apr 2019


Article type: Paper
DOI: 10.1039/C9NJ00561G
Citation: New J. Chem., 2019, Accepted Manuscript

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    Polydopamine-coated NaGdF4:Dy for T1/T2-weighted MRI/CT Multimodal Imaging-guided Photothermal Therapy

    W. Lu, Y. Liao, C. Jiang, R. Wang, X. Shan, Q. Chen, G. Sun and J. Liu, New J. Chem., 2019, Accepted Manuscript , DOI: 10.1039/C9NJ00561G

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