A diversity-oriented novel regioselective synthesis of sulfonamide–thiazolidinone hybrids†
Abstract
An efficient multicomponent synthesis of sulfonamide–thiazolidinone hybrids has been achieved by a one-pot reaction of sulfonyl hydrazides, isothiocyanates, and dialkyl acetylene dicarboxylates under catalyst-free conditions at room temperature. The method creates two new C–N and one C–S bonds in a single operation, and is endowed with excellent regioselectivity.