Issue 17, 2019

Metal-free, green and efficient oxidative α halogenation of enaminones by halo acid and DMSO

Abstract

Metal free oxidative halogenation of N-aryl enaminones has been demonstrated using a DMSO–halo acid combination under mild reaction conditions. This strategy allows a facile halogenation of enaminones through α functionalization leading to a broad range of α-halo-N-aryl substituted enaminones in good to excellent yields in a short period of time. Additionally, the use of readily available and inexpensive HX and DMSO makes this system more (atom economical) practical. The present method is a straightforward approach and is also applied for the synthesis of chromenone derivatives in excellent yields.

Graphical abstract: Metal-free, green and efficient oxidative α halogenation of enaminones by halo acid and DMSO

Supplementary files

Article information

Article type
Paper
Submitted
19 Dec 2018
Accepted
16 Mar 2019
First published
08 Apr 2019

New J. Chem., 2019,43, 6563-6568

Metal-free, green and efficient oxidative α halogenation of enaminones by halo acid and DMSO

G. S. Sorabad and M. R. Maddani, New J. Chem., 2019, 43, 6563 DOI: 10.1039/C8NJ06412A

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