Jump to main content
Jump to site search


Diastereoselective synthesis of bis(α-aminophosphonates) by lipase catalytic promiscuity

Author affiliations

Abstract

New bis(α-aminophosphonates) were directly prepared with high diastereoselectivity by lipase catalytic promiscuity in the presence of immobilized Candida antarctica lipase. We focused on the multi-component Kabachnik–Fields reaction using various aldehydes, benzidine, and diethylphosphite in one pot. The reaction proceeded with short reaction times with good to excellent yields. The CAL-B was easily recovered and reused several times. A total diastereoselectivity was observed for bis(α-aminophosphonates) 4a, 4c, 4h, 4i, 4k and was high for 4b, 4f and 4j.

Graphical abstract: Diastereoselective synthesis of bis(α-aminophosphonates) by lipase catalytic promiscuity

Back to tab navigation

Supplementary files

Publication details

The article was received on 10 Dec 2018, accepted on 21 Apr 2019 and first published on 14 May 2019


Article type: Paper
DOI: 10.1039/C8NJ06235H
New J. Chem., 2019, Advance Article

  •   Request permissions

    Diastereoselective synthesis of bis(α-aminophosphonates) by lipase catalytic promiscuity

    R. Aissa, S. Guezane-Lakoud, E. Kolodziej, M. Toffano and L. Aribi-Zouioueche, New J. Chem., 2019, Advance Article , DOI: 10.1039/C8NJ06235H

Search articles by author

Spotlight

Advertisements