Jump to main content
Jump to site search


Superb-selective Chemodosimetric Signaling of Sulfide in Absence and in Presence of CT-DNA and Imaging in Living Cells by Plant Alkaloid Berberine Analogue

Abstract

The present manuscript reports a lucrative design of a colorimetric and ratiometric chemodosimeter, 9-O-(2, 4-dinitrobenzenesulfonyl) berberrubine (BER-S) with excellent water solubility for superb selective detection of sulfide through a color alteration from yellow to red with a well limit of detection (LOD) of 56 nM in CP buffer solution (10mM, pH 7.2). Interestingly, this work also includes a smart “turn-on” emission probe (BER-S/DNA complex) showing well linearity with an excellent LOD of 46 nM for recognizing sulfide anion. The probes, BER-S and BER-S/DNA complex displayed no interfering effect by other analytes and sulfur-containing inorganic compounds like thiols. IR, HRMS, and DFT for the probe, BER-S and time-resolve fluorescence lifetime measurement and fluorescence titration for the probe, BER-S/DNA complex were used for elucidating their sensing mechanism. The detection of S2- in waste, tap and drinking water by BER-S indicates its potential application in real sample analysis. The concentration variant cell imaging experiment (eye-catching red fluorescence) verified its cell-membrane permeability and capability of S2- imaging in a living cell. This reaction-based sensing strategy in the presence of DNA may provide a hopeful platform for the design of fluorescent chemodosimeter for extensive anion targets.

Back to tab navigation

Supplementary files

Publication details

The article was received on 03 Dec 2018, accepted on 03 Jan 2019 and first published on 03 Jan 2019


Article type: Paper
DOI: 10.1039/C8NJ06120C
Citation: New J. Chem., 2019, Accepted Manuscript
  •   Request permissions

    Superb-selective Chemodosimetric Signaling of Sulfide in Absence and in Presence of CT-DNA and Imaging in Living Cells by Plant Alkaloid Berberine Analogue

    G. C. Jana, M. Khatun, S. Nayim, S. Das, A. Maji, M. Beg, A. Patra, P. Bhattacherjee, K. Bhadra and M. Hossain, New J. Chem., 2019, Accepted Manuscript , DOI: 10.1039/C8NJ06120C

Search articles by author

Spotlight

Advertisements