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Issue 5, 2019
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Superb-selective chemodosimetric signaling of sulfide in the absence and in the presence of CT-DNA and imaging in living cells by a plant alkaloid berberine analogue

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Abstract

The present manuscript reports a lucrative design of a colorimetric and ratiometric chemodosimeter, 9-O-(2,4-dinitrobenzenesulfonyl)berberrubine (BER-S), with excellent water solubility for the superb selective detection of sulfides through a color alteration from yellow to red with a good limit of detection (LOD) of 56 nM in CP buffer solution (10 mM, pH 7.2). Interestingly, this work also includes a smart “turn-on” emission probe (BER-S/DNA complex) showing good linearity with an excellent LOD of 46 nM for recognizing sulfide anions. The probes, BER-S, and BER-S/DNA complex, displayed no interfering effect by other analytes or sulfur-containing inorganic compounds, like thiols. Characterization was carried out using IR, HRMS, and DFT for the BER-S probe, and time-resolved fluorescence lifetime measurement and fluorescence titration for the BER-S/DNA complex probe for elucidating their sensing mechanism. The detection of S2− in waste, tap, and drinking water by BER-S indicated its potential application in real sample analysis, while concentration variant cell imaging experiments (naked-eye red fluorescence) verified its cell-membrane permeability and capability for S2− imaging in living cells. This reaction-based sensing strategy in the presence of DNA may provide a potential platform for the design of a fluorescent chemodosimeter for extensive anion targets.

Graphical abstract: Superb-selective chemodosimetric signaling of sulfide in the absence and in the presence of CT-DNA and imaging in living cells by a plant alkaloid berberine analogue

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Publication details

The article was received on 03 Dec 2018, accepted on 03 Jan 2019 and first published on 03 Jan 2019


Article type: Paper
DOI: 10.1039/C8NJ06120C
Citation: New J. Chem., 2019,43, 2368-2380

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    Superb-selective chemodosimetric signaling of sulfide in the absence and in the presence of CT-DNA and imaging in living cells by a plant alkaloid berberine analogue

    G. C. Jana, M. Khatun, S. Nayim, S. Das, A. Maji, M. Beg, A. Patra, P. Bhattacharjee, K. Bhadra and M. Hossain, New J. Chem., 2019, 43, 2368
    DOI: 10.1039/C8NJ06120C

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