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Issue 8, 2019
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Nickel-catalyzed regioselective C–H halogenation of electron-deficient arenes

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Abstract

A straightforward Ni(II)-catalyzed general strategy was developed for the ortho-halogenation of electron-deficient arenes with easily available halogenating reagents N-halosuccinimides (NXS; X = Br, Cl and I). The transformation was highly regioselective and a wide substrate scope and functional group tolerance were observed. This discovery could be of great significance for the selective halogenation of amides, benzoic esters and other substances with guiding groups. Mechanistic investigations were also described.

Graphical abstract: Nickel-catalyzed regioselective C–H halogenation of electron-deficient arenes

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Publication details

The article was received on 28 Nov 2018, accepted on 24 Jan 2019 and first published on 25 Jan 2019


Article type: Paper
DOI: 10.1039/C8NJ06023A
Citation: New J. Chem., 2019,43, 3462-3468

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    Nickel-catalyzed regioselective C–H halogenation of electron-deficient arenes

    Z. Li, P. Wu and C. Cai, New J. Chem., 2019, 43, 3462
    DOI: 10.1039/C8NJ06023A

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