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Application of ZIF-8-graphene oxide sponge for solid phase extraction method to the analysis of sex hormones in milk and milk products by high-performance liquid chromatography

Abstract

Zeolitic imidazolate framework-8 (ZIF-8) incorporated graphene oxide sponge (GOS) nanocomposite (ZIF-8-GOS) was synthesized successfully by simple one-pot preparation method. Compared with the raw materials (ZIF-8 and GOS), ZIF-8-GOS nanocomposite has very large surface area (1660 m2 g-1), super-high pore size (14.95 nm) and pore volume (6.21 cm3 g-1). Based on it, a method of ZIF-8-GOS for solid phase extraction (SPE)-high performance liquid chromatography (HPLC) was established for the analysis of five sex hormones in milk and milk products. The main experimental parameters that can affect the solid extraction process were optimized detailedly. From the comparison of ZIF-8, GOS and commercial C18 SPE cartridges, the ZIF-8-GOS adsorbents showed the best compromise between selectivity and efficiency for target analytes. The analytical performance showed low limits of detection (0.52-2.11 μg L-1) and the limits of quantification (1.75-6.97 μg L-1), as well as good linear ranges (10.0 - 3000 μg L-1 for most sex hormones except Nandrolone from 5.0-3000 μg L-1) with remarkable linear correlation coefficients (r>0.9998). Excellent repeatability were also achieved through intra-day (RSD<0.39%) and inter-day (RSD<3.86%) experiments. The application of the proposed analytical approach on milk and milk products, the results revealed satisfactory recoveries and sensitivity at trace level, with the detection of some of the target compounds, which demonstrate good application potential of ZIF-8-GOS adsorbent in trace analysis of organic contaminants.

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Supplementary files

Publication details

The article was received on 23 Nov 2018, accepted on 04 Jan 2019 and first published on 04 Jan 2019


Article type: Paper
DOI: 10.1039/C8NJ05940C
Citation: New J. Chem., 2019, Accepted Manuscript
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    Application of ZIF-8-graphene oxide sponge for solid phase extraction method to the analysis of sex hormones in milk and milk products by high-performance liquid chromatography

    X. Wang, J. Wang, T. Du, H. Kou, X. Du and X. Lu, New J. Chem., 2019, Accepted Manuscript , DOI: 10.1039/C8NJ05940C

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