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Ellagic Acids micro and nano formulations with amazingly increased water solubility by its entrapment in pectin or non-PAMAM dendrimers eligible for clinical applications

Abstract

Ellagic acid (EA) is a bioactive natural polyphenol owing antioxidant and other several healthy properties that, unfortunately cannot be exploited for in vivo therapeutic applications because of EA poor water solubility and accordingly low bioavailability. Aiming to increase EA solubility, an EA solid microdispersion was realized employing only water and low methoxylated pectin as food compatible excipient by applying spray drying technology. It showed a 22% (w/w) Drug Loading (DL), water solubility 30 times improved and remarkable radical scavenging activity. Subsequently, adopting non-PAMAM hydrophilic and amphiphilic dendrimers as nanocontainers, two EA nanodipersions were achieved (60-70 nm) endowed with 46 and 53% (w/w) DL, water solubility from 300 to 1000 times higher than free EA and good antioxidant power. In both cases, toxic agents as Castor oil, Tween 80 or the extensively used but not so safe PEG400 were avoided and no previously used carriers, β-cyclodextrins included, were adopted. The prepared micro and nanodispersions showed a water solubility never obtained before and represent non-toxic EA reservoirs suitable for food and biomedical applications respectively.

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Supplementary files

Publication details

The article was received on 07 Nov 2018, accepted on 07 Jan 2019 and first published on 08 Jan 2019


Article type: Paper
DOI: 10.1039/C8NJ05657A
Citation: New J. Chem., 2019, Accepted Manuscript
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    Ellagic Acids micro and nano formulations with amazingly increased water solubility by its entrapment in pectin or non-PAMAM dendrimers eligible for clinical applications

    S. Alfei, F. Turrini, S. Catena, P. Zunin, B. Parodi, G. Zuccari, A. Pittaluga and R. Boggia, New J. Chem., 2019, Accepted Manuscript , DOI: 10.1039/C8NJ05657A

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