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Boranephosphonate DNA: A versatile unnatural internucleotide linkage

Abstract

Boranephosphonate (bp) is a new class of unnatural internucleotide linkage where one of the oxygen of phosphodiester linkage is replaced by electron deficient borane (BH3) group. These unnatural internucleotide linkages are resistance to nuclease, RNase H active and hydrophobic which significantly enhances the cellular uptake. The bp-linked oligo can be synthesized by both enzymatically and chemically. Like borane (BH3) and diborane (B2H6) reagent, the borane group (BH3) in boranephosphonate oligo retains its reactivity towards specific substrate. BpDNA reduces metal ions such as Au(III), Ag(I), and Pt(II) and produce the corresponding metal nanoparticles which enables the DNA mediated morphology control and spatial positioning of nanoparticles and DNA nanostructures. Moreover, the bp-diesters also undergo oxidative substitution with various nucleophiles such as amines, alcohols, thiols etc. upon activation by iodine which leads to a route for postsynthetic modification of DNA, including DNA functionalization. This focus article discusses some of the recent research works of bp-oligo synthesis and its application.

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Publication details

The article was received on 02 Nov 2018, accepted on 02 Feb 2019 and first published on 05 Feb 2019


Article type: Focus
DOI: 10.1039/C8NJ05575K
Citation: New J. Chem., 2019, Accepted Manuscript

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    Boranephosphonate DNA: A versatile unnatural internucleotide linkage

    R. Kundu, New J. Chem., 2019, Accepted Manuscript , DOI: 10.1039/C8NJ05575K

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