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Designing biocompatible sterile organogel - bigel formulations for drug delivery applications using green protocol

Abstract

The present article discusses the formation of the bigel formulation for drug delivery applications by a newly developed green approach using the gamma radiation induced crosslinking. The bigels were prepared by using olive oil/sorbitan-monopamitate/sterculia gum that are designated as a green alternative renewable materials.The polymer samples were characterized by Cryo-SEMs, FTIR, 13C NMR, TGA, DTG, DSC, microscopic analysis and swelling studies. The release profile of drug moxifloxacin was determined along with the evaluation of various biomedical properties including biocompatibility, mucoadhesion, antioxidant and mechanical properties.The release profile of drug moxifloxacin from olive oil-SMP-sterculia-cl-poly(AAm) bigels followed non-Fickian diffusion mechanism. The release profile of drug from drug loaded olive oil-SMP-sterculia-cl-poly (AAm) bigels was best fitted in Higuchi kinetic model. The results indicated that the sterile and pure bigel formulations could be used for gastrointestinal drug delivery system due to their haemocompatible, non-haemolytic, mucoadhesive, antioxidant and viscoelastic nature.

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Publication details

The article was received on 31 Oct 2018, accepted on 08 Jan 2019 and first published on 08 Jan 2019


Article type: Paper
DOI: 10.1039/C8NJ05480K
Citation: New J. Chem., 2019, Accepted Manuscript
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    Designing biocompatible sterile organogel - bigel formulations for drug delivery applications using green protocol

    B. Singh and R. kumar, New J. Chem., 2019, Accepted Manuscript , DOI: 10.1039/C8NJ05480K

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