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Issue 3, 2019
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An L-cysteine-mediated iodide-catalyzed reaction for the detection of I

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Abstract

In this study, a highly selective and eco-friendly fluorescent sensor consisting of upconversion (UCNPs) and gold nanoparticles (AuNPs) was developed for the detection of iodide (I). The negatively charged AuNPs were able to electrostatically adsorb on the positively charged UCNPs, leading to the fluorescence quenching of the UCNPs. In the presence of L-cysteine, AuNPs were released from the surface of the UCNPs and aggregated due to the Au–S interactions that occurred between the AuNPs and L-cysteine, which resulted in the fluorescence recovery of the UCNPs. Upon the addition of I, the fluorescence of the UCNPs was gradually quenched meaning that I catalyzes the oxidation of L-cysteine, preventing the aggregation of AuNPs and forming a fluorescence resonance energy transfer system. The I-catalyzed oxidation reaction provides a method for the L-cysteine-triggered sensor to detect I, using L-cysteine to modulate the fluorescence signal in an eco-friendly manner. Based on the above special detection strategies, this sensor has excellent selectivity for I even in a complex matrix such as urine, which is much better than most assays for I. Under the optimal conditions, the sensor allows the quantitative analysis of I with a detection limit of 55 nM. The high selectivity, sensitivity and environmental friendliness of the sensor proves that it has the potential for the detection of I in actual samples. Most importantly, the excellent results of the sensor for the detection of I in urine prove that the probe can be used as an ideal tool in clinic diagnoses.

Graphical abstract: An l-cysteine-mediated iodide-catalyzed reaction for the detection of I−

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Publication details

The article was received on 29 Sep 2018, accepted on 25 Nov 2018 and first published on 04 Dec 2018


Article type: Paper
DOI: 10.1039/C8NJ04944K
Citation: New J. Chem., 2019,43, 1398-1403
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    An L-cysteine-mediated iodide-catalyzed reaction for the detection of I

    K. He, H. Chen, C. Wu, M. Liu and Y. Zhang, New J. Chem., 2019, 43, 1398
    DOI: 10.1039/C8NJ04944K

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