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Magnetic Particle Ornamented Dual Stimuli Responsive Nanogel for Controlled Anticancer Drug Delivery

Abstract

A series of spherical magneto responsive nanogels are fabricated by formulating a different sets of star block copolymer (BCP) based on pentaerythritol-poly(ε-caprolactone)-b-poly(acrylic acid) (PE-PCL-b-PAA) combined with amine functionalized magnetic nanoparticle (MNP) for targeted cancer therapy. Superparamagnetic nanoparticles, Fe3O4 (5 ± 0.5 nm) was modified with (3-Aminopropyl) trimethoxy silane to introduce the amine functionality into the system and also imparts colloidal stability. In the star block copolymer, the hydrophilic poly(acrylic acid) chain length has been architecture in such a way so that it can accommodate large number of amine functionalized magnetic nanoparticles. The hydrodynamic size of the nanogel has been observed in the range of 65 ± 2 nm to 616 ± 7 nm. The as prepared nanogel has been employed to deliver an anticancer drug, Doxorubicin (DOX). A maximum of 20% of DOX encapsulation has been observed. In presence of physiological pH of the cancer cell (pH 5), the nanogel is able to deliver 73% of drug @ 24 h which is further enhanced in the existence of external static magnetic field (76% release). Under the influence of high frequency alternating magnetic (HFAMF) field the in-vitro drug release rate is 56% / h. The low viscosity (0.21 Pa-s) at high shear rate (1000 S-1) makes the nanogel suitable for painless injection. The pristine nanogel shows about 80% of cell viability against C6 glioma cell line. The magnetic field induced targeting effect (cell uptake) of the fabricated nanogel has been visualized by fluorescence confocal microscopy. The therapeutic effect of the DOX loaded nanogel has been examined against the C6 glioma cell line and it is found that DOX loaded magnetic nanogel having a composition of , PE-PCL20-b-PAA180 with 10% amine modified Fe3O4 (MRG6) shows selectively high toxic (IC50 = 3.85 μg/mL) effect towards the C6 glioma cell line. This kind of new class of magneto nanogel can pave a new direction in the MRI-guided drug delivery system.

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Supplementary files

Publication details

The article was received on 23 Sep 2018, accepted on 07 Jan 2019 and first published on 09 Jan 2019


Article type: Paper
DOI: 10.1039/C8NJ04841J
Citation: New J. Chem., 2019, Accepted Manuscript
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    Magnetic Particle Ornamented Dual Stimuli Responsive Nanogel for Controlled Anticancer Drug Delivery

    P. Mandal, S. Maji, S. Panja, O. P. bajpai, T. K. Maiti and S. Chattopadhyay, New J. Chem., 2019, Accepted Manuscript , DOI: 10.1039/C8NJ04841J

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