Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 1, 2019
Previous Article Next Article

A transition metal-free approach towards synthesis of β-carboline tethered 1,3,4-oxadiazoles via oxidative C–O bond formation

Author affiliations

Abstract

An efficient protocol has been developed for one-pot synthesis of biologically interesting β-carboline substituted 1,3,4-oxadiazoles via an I2-assisted oxidative C–O bond formation strategy. This metal-free sequential approach is found to be compatible with diversely substituted 1-formyl β-carbolines and aromatic as well as aliphatic hydrazides, providing access to a variety of multifunctional β-carboline linked 1,3,4-oxadiazole derivatives in good to excellent yields. The methodology was found to be applicable to gram scale synthesis of β-carboline substituted 1,3,4-oxadiazole derivatives. Additionally, β-carboline C1 linked 2-amino-1,3,4-oxadiazoles and bis-1,3,4-oxadiazoles were also synthesized using the same strategy.

Graphical abstract: A transition metal-free approach towards synthesis of β-carboline tethered 1,3,4-oxadiazoles via oxidative C–O bond formation

Back to tab navigation

Supplementary files

Publication details

The article was received on 22 Aug 2018, accepted on 06 Nov 2018 and first published on 16 Nov 2018


Article type: Paper
DOI: 10.1039/C8NJ04294B
Citation: New J. Chem., 2019,43, 93-102

  •   Request permissions

    A transition metal-free approach towards synthesis of β-carboline tethered 1,3,4-oxadiazoles via oxidative C–O bond formation

    D. Singh, S. K. Tiwari and V. Singh, New J. Chem., 2019, 43, 93
    DOI: 10.1039/C8NJ04294B

Search articles by author

Spotlight

Advertisements