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Self assembled transition metal dithiocarbamates of pyridine-3-carboxamide: Synthesis, spectral characterization, thermal and biological studies

Abstract

A novel bidentate dithiocarbamato ligand (ndtc) derived from pyridine-3-carboxamide, (nicotinamide), by insertion reaction of Carbon disulfide and its subsequent self-assembled first row transition metal complexes having the formula M(ndtc)2 [where M = Co(II), Ni(II), Cu(II0 and Zn(II) ions] have been synthesized and characterized by using various spectral techniques. The facile reaction between the transition metal halide and ndtc in 1:2 molar ratios yielded the aforesaid complexes in high yields. The formation of single product was confirmed by thin layer chromatography. CHNS, IR, NMR spectra (1H and 13C), TGA/DTA, XRD, UV–visible spectra, magnetic moment and conductivity measurement data were calculated in order to ascertain the proposed structure of the synthesized complexes. On the basis of above studies the complexes have been found to possess octahedral arrangement excepting Cu(II) ion which is found to have a square-planar structure. The dithiocarbamato moiety has been found to coordinate in a bidentate symmetrical fashion with the metal ions in all the complexes. The complexes have been screened against a variety of human cancer cell lines like human hepatocellular carcinoma (Hep3B), human breast adenocarcinoma (MCF7) and normal cells (PBMC). The complexes displayed moderate to good cytotoxicity on cancer cell lines. However, Cu(ndtc)2 was found to be most potent on MCF7 with IC50 value, 3.56±1.1500, while Zn(ndtc)2 was most potent against liver and cervical cancer cell lines with IC50 values, 2.32±1.5000 and 3.58±1.6100 in micro-molar concentrations, respectively. The antioxidant potential of the ndtc and its metal complexes have been carried out using DPPH and Cu(ndtc)2 was found to be most efficient. Moreover, molecular docking simulations were also performed for the ndtc and its complexes which fortify the findings of cytotoxicity.

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Publication details

The article was received on 22 Jul 2018, accepted on 08 Jan 2019 and first published on 11 Jan 2019


Article type: Paper
DOI: 10.1039/C8NJ03660H
Citation: New J. Chem., 2019, Accepted Manuscript

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    Self assembled transition metal dithiocarbamates of pyridine-3-carboxamide: Synthesis, spectral characterization, thermal and biological studies

    A. Kareem, S. A. A. Nami, M. S. Khan, S. A. BHAT, A. U. Mirza and N. Nishat, New J. Chem., 2019, Accepted Manuscript , DOI: 10.1039/C8NJ03660H

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