ROS Self-Generation and Hypoxia Self-Enhanced Biodegradable Magnetic Nanotheranostics for Targeted Tumor Therapy
Amelioration of solid tumor hypoxia is one of the promising therapeutic strategies for malignant tumor ablation. Especially, reactive oxygen species (ROS)-induced apoptosis has been proved an efficient tumor therapeutic approach, relying on the advanced drug delivery or rapid production of ROS at the tumor region. However, the ROS generation is severely limited by tumor hypoxia. Herein, a new nanostructure based on biodegradable mesoporous magnetic nanocubes (MMNCs) is designed for ROS self-generation and self-enhancement magnetic thermotherapy. Typically, Vitamin c (Vc) locked in MMNCs with phase-change materials (PCM) could be triggered by hyperthermia under an alternating magnetic field (AMF), serving as original source for ROS (H2O2) generation. Next, the MMNCs possess Fenton reagent-like activity under acidic environment for ROS self-enhancement, which causes severe damage to tumor cells. The multifunctional nanotheranostics exhibit remarkable hyperthermia and enhanced ROS synergistic therapy efficiency. Furthermore, the nanoplatform demonstrates good biodegradability under acidic tumor microenvironment condition. This finding highlights the great potential of Vc loaded magnetic nanoparticles composites as efficient agents for tumor therapy. It opens an avenue for the design nanoformulation with ROS self-generation and self-enhancement in overcoming tumor hypoxia.