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Issue 1, 2020
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Biomimetic nanoparticle technology for cardiovascular disease detection and treatment

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Abstract

Cardiovascular disease (CVD), which encompasses a number of conditions that can affect the heart and blood vessels, presents a major challenge for modern-day healthcare. Nearly one in three people has some form of CVD, with many suffering from multiple or intertwined conditions that can ultimately lead to traumatic events such as a heart attack or stroke. While the knowledge obtained in the past century regarding the cardiovascular system has paved the way for the development of life-prolonging drugs and treatment modalities, CVD remains one of the leading causes of death in developed countries. More recently, researchers have explored the application of nanotechnology to improve upon current clinical paradigms for the management of CVD. Nanoscale delivery systems have many advantages, including the ability to target diseased sites, improve drug bioavailability, and carry various functional payloads. In this review, we cover the different ways in which nanoparticle technology can be applied towards CVD diagnostics and treatments. The development of novel biomimetic platforms with enhanced functionalities is discussed in detail.

Graphical abstract: Biomimetic nanoparticle technology for cardiovascular disease detection and treatment

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Article information


Submitted
05 May 2019
Accepted
28 Jun 2019
First published
28 Jun 2019

Nanoscale Horiz., 2020,5, 25-42
Article type
Review Article

Biomimetic nanoparticle technology for cardiovascular disease detection and treatment

J. H. Park, D. Dehaini, J. Zhou, M. Holay, R. H. Fang and L. Zhang, Nanoscale Horiz., 2020, 5, 25
DOI: 10.1039/C9NH00291J

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