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Issue 4, 2019
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Nanoscale antiadhesion properties of sophorolipid-coated surfaces against pathogenic bacteria

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Abstract

A current challenge in nanomedicine is to develop innovative strategies to fight infections caused by multiresistant bacterial pathogens. A striking example is antiadhesion therapy, which represents an attractive alternative to antibiotics to prevent and treat biofilm-associated infections on medical devices. By means of single-cell force nanoscopy, we demonstrate that sophorolipid (SL) biosurfactants feature unusually strong antiadhesion properties against Staphylococcus aureus and Escherichia coli, two nosocomial pathogens involved in catheter-related infections, which represent a major public health problem worldwide. We find that the nanoscale adhesion forces of single bacteria are much weaker on SL monolayers than on abiotic alkanethiol monolayers. The remarkable antifouling efficacy of SL-surfaces is likely to involve repulsive hydration forces associated with sophorose headgroups. We also show that, owing to their surfactant properties, soluble SLs block bacterial adhesion forces towards abiotic surfaces. Collectively, our single-cell experiments demonstrate that sophorolipids exhibit strong and versatile antiadhesion properties, making them promising candidates to design anti-infective biomaterials.

Graphical abstract: Nanoscale antiadhesion properties of sophorolipid-coated surfaces against pathogenic bacteria

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Publication details

The article was received on 07 Jan 2019, accepted on 05 Mar 2019 and first published on 25 Mar 2019


Article type: Communication
DOI: 10.1039/C9NH00006B
Nanoscale Horiz., 2019,4, 975-982
  • Open access: Creative Commons BY-NC license
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    Nanoscale antiadhesion properties of sophorolipid-coated surfaces against pathogenic bacteria

    C. Valotteau, N. Baccile, V. Humblot, S. Roelants, W. Soetaert, C. V. Stevens and Y. F. Dufrêne, Nanoscale Horiz., 2019, 4, 975
    DOI: 10.1039/C9NH00006B

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