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Engineering of Tai Chi-like Nanocarriers for Varisized Guests Delivery and Synergistic Eradication of Patients-Derived Hepatocellular Carcinoma

Abstract

During the different clinical manifestations and periods in the treatment of hepatocellular carcinoma (HCC), the species and doses of drugs could be optimized to realize the personalized therapy for an individual patient. Here, we firstly reported the Tai Chi-like ultrasmall nanoparticles-stacked oleic acid-NaYF4:Yb,Er@hollow porous SiO2 nanopaticles (Tai Chi-like OA-UCNPs@HPS NPs) with hydrophobic eccentric hollow structure and hydrophilic exterior surface possessing the wide pore size distribution via a novel method. The obtained NPs achieved the loading of the multiple varisized hydrophobic/hydrophilic guests into the discrete rooms and releasing each one from the independent channels to reduce the undesirable adverse effects of different guests, which greatly favored the selection of drugs for an individual patient and enhanced the synergistic theranostics. The in vitro and in vivo (cell line-derived xenograft and patients-derived xenograft models) results demonstrated that the HCPT/DOX-loaded NPs could act as the excellent theranostics agents for the multimodal imaging-guided synergic dual-drug cancer therapy of HCC. Meanwhile, the potential mechanisms of actions of the HCPT/DOX-loaded NPs after endocytosis by HCC cells were evaluated. The nanocomposite could further motivate the progress of new architectures of nanocarriers for varisized guests delivery and personalized treatment.

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Publication details

The article was received on 06 Dec 2018, accepted on 12 Apr 2019 and first published on 13 Apr 2019


Article type: Communication
DOI: 10.1039/C8NH00467F
Citation: Nanoscale Horiz., 2019, Accepted Manuscript

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    Engineering of Tai Chi-like Nanocarriers for Varisized Guests Delivery and Synergistic Eradication of Patients-Derived Hepatocellular Carcinoma

    X. Chen, X. Zhang, S. Li, L. Zhang, Q. Zhang, Z. Chen, L. Li, Z. Su, S. Cheng and C. Wang, Nanoscale Horiz., 2019, Accepted Manuscript , DOI: 10.1039/C8NH00467F

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