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Issue 3, 2019
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Reductive surfactant-assisted one-step fabrication of a BiOI/BiOIO3 heterojunction biophotocatalyst for enhanced photodynamic theranostics overcoming tumor hypoxia

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Abstract

Inorganic biophotocatalysts with suitable size are greatly attractive in photodynamic therapy (PDT) with enhanced permeability and retention effect and the capability to produce reactive oxygen species via type-I reaction for overcoming tumor hypoxia. Herein, we develop a facile one-step hydrothermal method to prepare biocompatible BiOI/BiOIO3 heterostructure nanocomposites (BB NCs) by introducing reductive trithiol-terminated poly-(methacrylic acid) (PTMP-PMAA) as the surfactant, which can reduce partial KIO3 (raw material) into KI, resulting in the generation of BiOI and BiOIO3 in one nanocomposite. Under irradiation with a 650 nm laser, the photogenerated holes/electrons of the agent can effectively generate hydroxyl radicals (˙OH) and singlet oxygen (1O2) through a type I and O2 self-supplying type II PDT process, respectively, under both normoxic and hypoxic environments, which could lead to a reduced mitochondrial membrane potential (MMP) and in turn inhibit the production of ATP to initiate the death of HeLa cells, eventually causing the complete destruction of the tumor at a low dose (0.64 mg kg−1). In addition, the agent also shows extraordinary computed tomography imaging capability due to the high X-ray absorption coefficient (∼41.39 HU L g−1). Our study provides a robust biowindow-responsive hypoxic tumor theranostic agent to break through the limitations of PDT.

Graphical abstract: Reductive surfactant-assisted one-step fabrication of a BiOI/BiOIO3 heterojunction biophotocatalyst for enhanced photodynamic theranostics overcoming tumor hypoxia

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Publication details

The article was received on 27 Nov 2018, accepted on 30 Jan 2019 and first published on 31 Jan 2019


Article type: Communication
DOI: 10.1039/C8NH00440D
Citation: Nanoscale Horiz., 2019,4, 720-726

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    Reductive surfactant-assisted one-step fabrication of a BiOI/BiOIO3 heterojunction biophotocatalyst for enhanced photodynamic theranostics overcoming tumor hypoxia

    W. Zhen, Y. Liu, X. Jia, L. Wu, C. Wang and X. Jiang, Nanoscale Horiz., 2019, 4, 720
    DOI: 10.1039/C8NH00440D

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