Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.



A novel strategy based on a ligand-switchable nanoparticle delivery system for deep tumor penetration

Author affiliations

Abstract

The poor tumor penetration of many nanomedicines severely limits their therapeutic efficiency. Although the combination of cell-penetrating peptides (CPPs) has been reported as a promising strategy to improve the penetration capability of nanoparticles, the nonspecific interactions of CPPs may reduce nanoparticles’ circulation time and increase their side effects, making them inapplicable in many in vivo settings. Herein, we report a ligand-switchable strategy to inhibit CPPs’ nonspecific interactions in the bloodstream and quickly reactivate their functions when entering into tumor sites. Due to the rapid phase transition of PAE, the CPPs can be completely hidden under the PEG corona in plasma, avoiding direct interaction with the immune cells and normal tissues. Once extravasation from blood vessels occurs, the acidic tumor microenvironment would trigger the exposure of the CPPs, promoting the diffusion of antitumor agents deep into the tumor sites. With this ligand-switchable property, nanocarriers are capable of achieving long durations of circulation, preferential accumulation and efficient tumor penetration simultaneously, giving rise to high antitumor activity and low adverse reactions, and also providing a universal approach to enable in vivo applications of CPPs as well as other nonspecific ligands.

Graphical abstract: A novel strategy based on a ligand-switchable nanoparticle delivery system for deep tumor penetration

Back to tab navigation

Supplementary files

Publication details

The article was received on 13 Nov 2018, accepted on 20 Dec 2018 and first published on 20 Dec 2018


Article type: Communication
DOI: 10.1039/C8NH00415C
Citation: Nanoscale Horiz., 2019, Advance Article

  •   Request permissions

    A novel strategy based on a ligand-switchable nanoparticle delivery system for deep tumor penetration

    Y. Ding, J. Liu, Y. Zhang, X. Li, H. Ou, T. Cheng, L. Ma, Y. An, J. Liu, F. Huang, Y. Liu and L. Shi, Nanoscale Horiz., 2019, Advance Article , DOI: 10.1039/C8NH00415C

Search articles by author

Spotlight

Advertisements