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Structural complementarity from DNA for directing two-dimensional polydopamine nanomaterials with biomedical applications

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Abstract

Mussel-inspired polydopamine (PDA) has great potential in constructing 2D nanomaterials under mild synthesis conditions (weakly alkaline pH and room temperature), due to the unique-layered structure during its self-polymerization. However, the manipulation of PDA oligomer's aggregation remains a great challenge. Motivated by the similarity in the inter-plane spacings (∼3.4–3.6 Å) of the subunits (base pairs for DNA and oligomers for PDA), we first demonstrate the synthesis of free-standing PDA nanoplatelets/sheets through solution-based supramolecular interactions guided by the structural complementarity of the subunit arrangements. The vertical interdigitation and lateral packing of PDA's primary planar structures were involved in the formation process directed by DNA. This system provided us a new platform for understanding the self-assembly interactions between DNA and PDA and the construction of sophisticated 2D nanomaterials with excellent photothermal conversion properties for cancer inhibition applications.

Graphical abstract: Structural complementarity from DNA for directing two-dimensional polydopamine nanomaterials with biomedical applications

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Publication details

The article was received on 10 Oct 2018, accepted on 07 Dec 2018 and first published on 07 Dec 2018


Article type: Communication
DOI: 10.1039/C8NH00351C
Citation: Nanoscale Horiz., 2019, Advance Article
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    Structural complementarity from DNA for directing two-dimensional polydopamine nanomaterials with biomedical applications

    T. Ding, Y. Xing, Z. Wang, H. Guan, L. Wang, J. Zhang and K. Cai, Nanoscale Horiz., 2019, Advance Article , DOI: 10.1039/C8NH00351C

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