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Ultrasound Activation of Liposome for Enhanced Ultrasound Imaging and Synergistic Gas and Sonodynamic Cancer Therapy

Abstract

Ultrasound (US) imaging is widely applied in hospital and clinical settings due to its non-invasiveness, controllability, and high tissue-penetrating ability. Moreover, sonodynamic therapy (SDT) activated by US is a safe cancer therapeutic strategy able to overcome the restrictions of traditional photo-triggered therapeutic modalities such as their relatively low penetration. Simultaneous US-activated imaging and therapy in a single theranostic nanoplatform is a promising strategy for cancer therapy. Herein, we developed a 2,2’-azobis[2-(2-imidazolin-2-yl)propane] dihydrochloride (AIPH)-loaded liposome (Lip-AIPH) “nanobomb” that can simultaneously generate gas bubbles and a high concentration of reactive oxygen species (ROS) under US irradiation. In vivo experimental results confirmed that the generated gas and alkyl radicals were independent of oxygen generation and were successfully used for synergistic gas therapy and SDT in a hypoxic tumor microenvironment. More importantly, the generated gas bubbles, when used as a powerful US contrast agent, greatly enhanced US contrast to guide cancer therapy. As a US-activated theranostic agent, the ‘nanobomb’ enhanced US imaging and exhibited an improved anticancer efficacy, and it may prove promising for US imaging-guided hypoxic tumor therapy with deep tissue penetration.

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Publication details

The article was received on 08 Oct 2018, accepted on 31 Jan 2019 and first published on 01 Feb 2019


Article type: Communication
DOI: 10.1039/C8NH00340H
Citation: Nanoscale Horiz., 2019, Accepted Manuscript

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    Ultrasound Activation of Liposome for Enhanced Ultrasound Imaging and Synergistic Gas and Sonodynamic Cancer Therapy

    X. Lin, Y. Qiu, L. Song, S. Chen, X. Chen, G. Huang, J. Song, X. S. Chen and H. Yang, Nanoscale Horiz., 2019, Accepted Manuscript , DOI: 10.1039/C8NH00340H

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