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On the advancement of polymeric bicontinuous nanospheres toward biomedical applications

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Abstract

Self-assembled soft nanocarriers that are capable of simultaneous encapsulation of both lipophilic and water soluble payloads have significantly enhanced controlled delivery applications in biomedicine. These nanoarchitectures, such as liposomes, polymersomes and cubosomes, are primarily composed of either amphiphilic polymers or lipids, with the polymeric variants generally possessing greater stability and control over biodistribution and bioresponsive release. Polymersomes have long demonstrated such advantages over their lipid analogs, liposomes, but only recently have bicontinuous nanospheres emerged as a polymeric cubic phase alternative to lipid cubosomes. In this review, we summarize the current state of the field for bicontinuous nanosphere formulation and characterization and suggest future directions for this nascent delivery platform as it is adopted for biomedical applications.

Graphical abstract: On the advancement of polymeric bicontinuous nanospheres toward biomedical applications

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Publication details

The article was received on 12 Sep 2018, accepted on 13 Nov 2018 and first published on 14 Nov 2018


Article type: Review Article
DOI: 10.1039/C8NH00300A
Citation: Nanoscale Horiz., 2019, Advance Article
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    On the advancement of polymeric bicontinuous nanospheres toward biomedical applications

    S. D. Allen, S. Bobbala, N. B. Karabin and E. A. Scott, Nanoscale Horiz., 2019, Advance Article , DOI: 10.1039/C8NH00300A

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