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Tuning the cationic interface of simple polydiacetylene micelles to improve siRNA delivery at the cellular level

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Abstract

Polydiacetylene micelles were assembled from four different cationic amphiphiles and photopolymerized to reinforce their architecture. The produced micelles were systematically investigated, in interaction with siRNAs, for intracellular delivery of the silencing nucleic acids. The performances of the carrier systems were rationalized based on the cell penetrating properties of the micelles and the nature of their cationic complexing group, responsible for efficient siRNA binding and further endosomal escape.

Graphical abstract: Tuning the cationic interface of simple polydiacetylene micelles to improve siRNA delivery at the cellular level

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Publication details

The article was received on 09 Sep 2019, accepted on 23 Sep 2019 and first published on 24 Sep 2019


Article type: Paper
DOI: 10.1039/C9NA00571D
Nanoscale Adv., 2019, Advance Article
  • Open access: Creative Commons BY license
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    Tuning the cationic interface of simple polydiacetylene micelles to improve siRNA delivery at the cellular level

    M. Hoang, M. Vandamme, G. Kratassiouk, G. Pinna, E. Gravel and E. Doris, Nanoscale Adv., 2019, Advance Article , DOI: 10.1039/C9NA00571D

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