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High-throughput chemical and chemoenzymatic approaches to saccharide-coated magnetic nanoparticles for MRI

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Abstract

There is a need for biofunctionalised magnetic nanoparticles for many biomedical applications, including MRI contrast agents that have a range of surface properties and functional groups. A library of eleven adducts, each formed by condensing a reducing sugar with a catechol hydrazide, for nanoparticle functionalisation has been created using a high-throughput chemical synthesis methodology. The enzymatic transformation of an N-acetylglucosamine (GlcNAc) adduct into an N-acetyllactosamine adduct by β-1,4-galactosyltransferase illustrates how chemoenzymatic methods could provide adducts bearing complex and expensive glycans. Superparamagnetic iron oxide nanoparticles (8 nm diameter, characterised by TEM, DLS and SQUID) were coated with these adducts and the magnetic resonance imaging (MRI) properties of GlcNAc-labelled nanoparticles were determined. This straightforward approach can produce a range of MRI contrast agents with a variety of biofunctionalised surfaces.

Graphical abstract: High-throughput chemical and chemoenzymatic approaches to saccharide-coated magnetic nanoparticles for MRI

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Publication details

The article was received on 14 Jun 2019, accepted on 29 Jul 2019 and first published on 29 Jul 2019


Article type: Paper
DOI: 10.1039/C9NA00376B
Nanoscale Adv., 2019, Advance Article
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    High-throughput chemical and chemoenzymatic approaches to saccharide-coated magnetic nanoparticles for MRI

    Thomas W. Fallows, A. J. McGrath, J. Silva, S. G. McAdams, A. Marchesi, F. Tuna, S. L. Flitsch, R. D. Tilley and S. J. Webb, Nanoscale Adv., 2019, Advance Article , DOI: 10.1039/C9NA00376B

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