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Relationship between structure and molecular interactions in monolayers of specially designed aminolipids

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Abstract

Artificial cationic lipids are already recognized as highly efficient gene therapy tools. Here, we focus on another potential use of aminolipids, in their electrically-uncharged state, for the formation of covalently cross-linked, one-molecule-thin films at interfaces. Such films are envisioned for future (bio-)materials applications. To this end, Langmuir monolayers of structurally different aminolipids are comprehensively characterized with the help of highly sensitive surface characterization techniques. Pressure-area isotherms, Brewster angle microscopy, grazing-incidence X-ray diffraction and infrared reflection–absorption spectrometry experiments provide a detailed, comparative molecular picture of the formed monolayers. This physico-chemical study highlights the relationship between chemical structures and intermolecular interactions, which can serve as a basis for the rational design of cross-linked thin films with precisely controlled properties.

Graphical abstract: Relationship between structure and molecular interactions in monolayers of specially designed aminolipids

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Publication details

The article was received on 05 Jun 2019, accepted on 23 Jul 2019 and first published on 23 Jul 2019


Article type: Paper
DOI: 10.1039/C9NA00355J
Nanoscale Adv., 2019, Advance Article
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    Relationship between structure and molecular interactions in monolayers of specially designed aminolipids

    C. Stefaniu, C. Wölk, G. Brezesinski and E. Schneck, Nanoscale Adv., 2019, Advance Article , DOI: 10.1039/C9NA00355J

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