Jump to main content
Jump to site search


Silicon carbide nanoparticles as a photoacoustic and photoluminescent dual-imaging contrast agent for long-term cell tracking

Author affiliations

Abstract

Silicon carbide nanoparticles (SiCNPs) are durable, physically resilient, chemically inert, and biocompatible. Silicon carbide particles smaller than 10 nm show photoluminescence due to quantum confinement effects and have been reported in imaging different cell lines. To further explore the potential of silicon carbide nanomaterials in cell imaging, we studied the photoluminescence and photoacoustic properties of three SiCNPs of approximately 30, 80, and 620 nm. All these SiCNPs show photoluminescence and photoacoustic signals, and the 620 nm silicon carbide nanoparticles (SiCNP620) show the highest photoluminescence and photoacoustic intensity. SiCNP620 is biocompatible with a good cell labeling capacity. It could image mesenchymal stem cells in vitro for more than 20 days via photoluminescence even when the cells were differentiated into adipocytes and osteocytes. The same SiCNP620 could also produce photoacoustic signals and track stem cells in vivo for over 14 days.

Graphical abstract: Silicon carbide nanoparticles as a photoacoustic and photoluminescent dual-imaging contrast agent for long-term cell tracking

Back to tab navigation

Publication details

The article was received on 11 Apr 2019, accepted on 14 Jul 2019 and first published on 25 Jul 2019


Article type: Paper
DOI: 10.1039/C9NA00237E
Nanoscale Adv., 2019, Advance Article
  • Open access: Creative Commons BY-NC license
  •   Request permissions

    Silicon carbide nanoparticles as a photoacoustic and photoluminescent dual-imaging contrast agent for long-term cell tracking

    F. Chen, E. R. Zhao, T. Hu, Y. Shi, D. J. Sirbuly and J. V. Jokerst, Nanoscale Adv., 2019, Advance Article , DOI: 10.1039/C9NA00237E

    This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements