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Issue 6, 2019
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Nanomaterial based aptasensors for clinical and environmental diagnostic applications

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Abstract

Nanomaterials have been exploited extensively to fabricate various biosensors for clinical diagnostics and food & environmental monitoring. These materials in conjugation with highly specific aptamers (next-gen antibody mimics) have enhanced the selectivity, sensitivity and rapidness of the developed aptasensors for numerous targets ranging from small molecules such as heavy metal ions to complex matrices containing large entities like cells. In this review, we highlight the recent advancements in nanomaterial based aptasensors from the past five years also including the basics of conventionally used detection methodologies that paved the way for futuristic sensing techniques. The aptasensors have been categorised based upon these detection techniques and their modifications viz., colorimetric, fluorometric, Raman spectroscopy, electro-chemiluminescence, voltammetric, impedimetric and mechanical force-based sensing of a multitude of targets are discussed in detail. The bio-interaction of these numerous nanomaterials with the aptameric component and that of the complete aptasensor with the target have been studied in great depth. This review thus acts as a compendium for nanomaterial based aptasensors and their applications in the field of clinical and environmental diagnosis.

Graphical abstract: Nanomaterial based aptasensors for clinical and environmental diagnostic applications

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Article information


Submitted
11 Mar 2019
Accepted
28 Apr 2019
First published
29 Apr 2019

This article is Open Access

Nanoscale Adv., 2019,1, 2123-2138
Article type
Review Article

Nanomaterial based aptasensors for clinical and environmental diagnostic applications

H. Kaur and M. Shorie, Nanoscale Adv., 2019, 1, 2123
DOI: 10.1039/C9NA00153K

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    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
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    [Original citation] - Published by The Royal Society of Chemistry.

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