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Issue 6, 2019
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The interplay between size and valence state on the antibacterial activity of sub-10 nm silver nanoparticles

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Abstract

Silver nanoparticles (AgNPs) have attracted enormous interest because of their excellent antibacterial properties, low cytotoxicity and limited evidence for resistance. As a general trend, smaller nanoparticles are considered to have stronger antibacterial activity. In this work we investigate whether this trend is valid for the sub-10 nm region by designing and synthesising three types of sub-10 nm AgNPs (∼1.87, ∼2.93 and ∼6.53 nm) to reveal the influence of size, valence state and structure on the antibacterial potency of AgNPs. We found that NPs with a size of ∼2.93 nm having a high concentration of silver in the first valence state presented the highest bacterial killing potency as well as low cytotoxicity to mammalian cells. The new insights presented in this study open future avenues for the engineering of highly potent silver nanoantibiotics that can be incorporated into future advanced medical devices and therapies capable of protecting patients from infections.

Graphical abstract: The interplay between size and valence state on the antibacterial activity of sub-10 nm silver nanoparticles

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Supplementary files

Article information


Submitted
11 Jan 2019
Accepted
16 Apr 2019
First published
30 Apr 2019

This article is Open Access

Nanoscale Adv., 2019,1, 2365-2371
Article type
Paper

The interplay between size and valence state on the antibacterial activity of sub-10 nm silver nanoparticles

H. Haidari, N. Goswami, R. Bright, Z. Kopecki, A. J. Cowin, S. Garg and K. Vasilev, Nanoscale Adv., 2019, 1, 2365
DOI: 10.1039/C9NA00017H

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