Issue 5, 2019

Bio-inspired temporal regulation of ion-transport in nanochannels


Temporal regulation of mass transport across the membrane is a vital feature of biological systems. Such regulatory mechanisms rely on complex biochemical reaction networks, often operating far from equilibrium. Herein, we demonstrate biochemical reaction mediated temporal regulation of mass transport in nanochannels of mesoporous silica sphere. The rationally designed nanochannels with pH responsive electrostatic gating are fabricated through a hetero-functionalization approach utilizing propylamine and carboxylic acid moieties. At basic pH, cationic small molecules can diffuse into the nanochannels which release back to the solution at acidic pH. The transient ion transport is temporally controlled using a base as fuel along with esterase enzyme as the mediator. The slow enzymatic hydrolysis of a dormant deactivator (ethyl acetate) determines the lifetime of transient encapsulated state, which can be programmed easily by modulating the enzymatic activity of esterase. This system represents a unique approach to create autonomous artificial cellular models.

Graphical abstract: Bio-inspired temporal regulation of ion-transport in nanochannels

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Article information

Article type
24 Dec 2018
11 Mar 2019
First published
12 Mar 2019
This article is Open Access
Creative Commons BY license

Nanoscale Adv., 2019,1, 1847-1852

Bio-inspired temporal regulation of ion-transport in nanochannels

K. P. Sonu, S. Vinikumar, S. Dhiman, S. J. George and M. Eswaramoorthy, Nanoscale Adv., 2019, 1, 1847 DOI: 10.1039/C8NA00414E

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