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Colorimetric sensing strategy for heparin assay based on PDDA-induced aggregation of gold nanoparticles

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Abstract

Herein, we report a highly sensitive colorimetric sensor for the detection of heparin based on its anti-aggregation effect of the PDDA–gold nanoparticle colloidal system. PDDA-induced non-crosslinking aggregation of gold nanoparticles is firstly investigated and the phenomenon of heparin mediated color recovery is then observed, which can be used to indicate the concentration of heparin. This method is proved to be highly sensitive and selective. Moreover, it has been successfully applied to determine human blood serum samples, the results of which demonstrate great potential practical utility with simple operations.

Graphical abstract: Colorimetric sensing strategy for heparin assay based on PDDA-induced aggregation of gold nanoparticles

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Publication details

The article was received on 23 Aug 2018, accepted on 29 Sep 2018 and first published on 01 Oct 2018


Article type: Communication
DOI: 10.1039/C8NA00162F
Citation: Nanoscale Adv., 2019, Advance Article
  • Open access: Creative Commons BY-NC license
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    Colorimetric sensing strategy for heparin assay based on PDDA-induced aggregation of gold nanoparticles

    X. Ma, X. Kou, Y. Xu, D. Yang and P. Miao, Nanoscale Adv., 2019, Advance Article , DOI: 10.1039/C8NA00162F

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