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Thiol-free oligonucleotide surface modification of gold nanoparticles for nanostructure assembly

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Abstract

Gold nanoparticles (AuNPs) decorated with thiol-modified DNA (HS-DNA) strands are an extensively studied, easily adjustable, and highly controllable material for constructing 3D nanostructures with various shapes and functions. However, few reproducible and robust methods involving DNA templates as a key reagent are available for obtaining 3D nanoparticle assemblies. It is still challenging to strictly control the number and location of DNA strands on the AuNP surface. Here, we introduce an efficient approach for the surface modification of AuNPs using unmodified DNA oligonucleotides by building DNA cages that trap the nanoparticles. This enables us to vary the process of nanostructure assembly and create anisotropic nanoparticles that are necessary for directed structure construction. This developed method simplifies the production process in comparison with conventional HS-DNA modification protocols and helps to precisely control the density and position of functional DNA strands designed for further hybridization with other AuNP conjugates.

Graphical abstract: Thiol-free oligonucleotide surface modification of gold nanoparticles for nanostructure assembly

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Publication details

The article was received on 13 Aug 2018, accepted on 19 Sep 2018 and first published on 20 Sep 2018


Article type: Paper
DOI: 10.1039/C8NA00148K
Citation: Nanoscale Adv., 2019, Advance Article
  • Open access: Creative Commons BY license
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    Thiol-free oligonucleotide surface modification of gold nanoparticles for nanostructure assembly

    A. O. Maslova and I. M. Hsing, Nanoscale Adv., 2019, Advance Article , DOI: 10.1039/C8NA00148K

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