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Anti-cancers activities of the metal-based complexes by regulating VEGF/VEGFR2 signaling pathway and apoptosis related factors Bcl-2, Bax, and Caspase-9 to inhibit angiogenesis and induce apoptosis

Abstract

Three novel single crystals of metal-based complexes Cu-1, Cu-2, and Co-1 were obtained and characterized. Compared with Cu-2 and Co-1, Cu-1 showed remarkable activities of anti-cervical cancer, anti-cisplatin-resistant non-small cell lung cancer and anti-angiogenesis by downregulating the expressions of the important proteins in VEGF/VEGFR2 signaling pathway to inhibit angiogenesis and to inhibit cancer cells proliferation, induce apoptosis, suppress migration and metastasis. Moreover, Cu-1 dramatically inhibited the expression of anti-apoptotic protein Bcl-2 and up-regulated the expressions of proapoptotic proteins caspase-9 and Bax to induce apoptosis of tumor cells, simultaneously decreased the density of endothelial cells to inhibit tumor angiogenesis in cisplatin-resistant tumors.

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Publication details

The article was received on 04 Oct 2019, accepted on 04 Nov 2019 and first published on 04 Nov 2019


Article type: Paper
DOI: 10.1039/C9MT00248K
Metallomics, 2019, Accepted Manuscript

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    Anti-cancers activities of the metal-based complexes by regulating VEGF/VEGFR2 signaling pathway and apoptosis related factors Bcl-2, Bax, and Caspase-9 to inhibit angiogenesis and induce apoptosis

    X. Qin, Y. Wang, H. Liu, Z. Luo, H. Li-Fang and M. Liu, Metallomics, 2019, Accepted Manuscript , DOI: 10.1039/C9MT00248K

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