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Issue 11, 2019
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Coordinative unsaturated CuI entities are crucial intermediates governing cell internalization of copper. A combined experimental ESI-MS and DFT study

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Abstract

Model peptides relevant to hCtr1 transchelate CuI from the anti-tumour [CuI(PTA)4]+ complex before metal internalization into tumor cells. ESI(+)MS experiments corroborated by DFT calculations indicate that tetracoordinated-CuII and linear-CuI arrangements of in situ generated copper-peptide products play a crucial role in promoting the transfer of copper from the terminal MDH portion into adjacent HSH peptide sequence.

Graphical abstract: Coordinative unsaturated CuI entities are crucial intermediates governing cell internalization of copper. A combined experimental ESI-MS and DFT study

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Publication details

The article was received on 20 Sep 2019, accepted on 23 Oct 2019 and first published on 23 Oct 2019


Article type: Communication
DOI: 10.1039/C9MT00236G
Metallomics, 2019,11, 1800-1804

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    Coordinative unsaturated CuI entities are crucial intermediates governing cell internalization of copper. A combined experimental ESI-MS and DFT study

    S. Carlotto, A. Bonna, K. Bossak-Ahmad, W. Bal, M. Porchia, M. Casarin and F. Tisato, Metallomics, 2019, 11, 1800
    DOI: 10.1039/C9MT00236G

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