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Hypothesis: entatic versus ecstatic states in metalloproteins

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Abstract

Over half a century ago the hypothesis was put forth that redox-active metal ions and multidentate protein ligands may combine to form a local state of entasis: an irregular symmetry intermediate between those dictated by coordination chemistry for the two redox states involved. Such an energetically poised domain would be at the basis of high activity (notably electron-transfer rates) in biological systems. Today the concept of the entatic state has become textbook material. Based on EPR spectroscopic data it is proposed here that poised, entatic states may only be of marginal existence; rather the occurrence of relatively wide distributions of coordination geometries (or: ecstatic states) afford a stochastic tuning of structure towards low-energy unimolecular transition states.

Graphical abstract: Hypothesis: entatic versus ecstatic states in metalloproteins

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Publication details

The article was received on 19 Aug 2019, accepted on 03 Oct 2019 and first published on 09 Oct 2019


Article type: Perspective
DOI: 10.1039/C9MT00208A
Metallomics, 2019, Advance Article
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    Hypothesis: entatic versus ecstatic states in metalloproteins

    W. R. Hagen, Metallomics, 2019, Advance Article , DOI: 10.1039/C9MT00208A

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